Ischemia-Related Brain Damage in Preterm and Term Infants
نویسندگان
چکیده
The maturational stage of the brain at the time of injury plays a key role in the pattern of brain damage in humans, including regional and cell-type–specific susceptibility. In this minireview, we will summarize available models of preterm and at-term ischemic brain injury in rodents and in larger species and discuss how maturation stage of the brain at the time of an insult affects the underlying excitotoxic and inflammatory injury signatures. We will review pros and cons of animal modeling for advancing the understanding of the mechanisms of hypoxic–ischemic encephalopathy (HIE) and stroke in human infants.
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